Under pressure from the chemical industry, the Environmental Protection Agency has dismissed an outspoken scientist who chaired a federal panel responsible for helping the agency determine the dangers of a flame retardant widely used in electronic equipment.

Toxicologist Deborah Rice was appointed chair of an EPA scientific panel reviewing the chemical a year ago. Federal records show she was removed from the panel in August after the American Chemistry Council, the lobbying group for chemical manufacturers, complained to a top-ranking EPA official that she was biased.

The chemical, a brominated compound known as deca, is used in high volumes worldwide, largely in the plastic housings of television sets.

Rice, an award-winning former EPA scientist who now works at the Maine Department of Health and Human Services, has studied low doses of deca and reported neurological effects in lab animals. Last February, around the time the EPA panel was convened, Rice testified before the Maine Legislature in support of a state ban on the compound because scientific evidence shows it is toxic and accumulating in the environment and people.

Chemical industry lobbyists say Rice's comments to the Legislature, as well as similar comments to the media, show that she is a biased advocate who has compromised the integrity of the EPA's review of the flame retardant.

The EPA is in the process of deciding how much daily exposure to deca is safe -- a controversial decision, expected next month, that could determine whether it can still be used in consumer products. The role of the expert panel was to review and comment on the scientific evidence.

EPA officials removed Rice because of what they called "the perception of a potential conflict of interest." Under the agency's handbook for advisory committees, scientific peer reviewers should not "have a conflict of interest" or "appear to lack impartiality."

EPA officials were not available for comment Thursday.

Environmentalists accuse the EPA of a "dangerous double standard," because under the Bush administration, many pro-industry experts have served on the agency's scientific panels.

The Environmental Working Group, a Washington, D.C.-based advocacy group, reviewed seven EPA panels created last year and found 17 panelists who were employed or funded by the chemical industry or had made public statements that the chemicals they were reviewing were safe. In one example, an Exxon Mobil Corp. employee served on an EPA expert panel responsible for deciding whether ethylene oxide, a chemical manufactured by Exxon Mobil, is a carcinogen.

Sonya Lunder, a senior analyst at the Environmental Working Group, called it "deeply problematic from the public interest perspective" for the EPA to dismiss scientists who advocate protecting health while appointing those who promote industry views.

Lunder said it is unprecedented for the EPA to remove an expert for expressing concerns about the potential dangers of a chemical.

"It's a scary world if we create a precedent that says scientists involved in decision-making are perceived to be too biased," she said.

Rice was unavailable for comment Thursday.

In addition to her testimony for the Maine Legislature, Rice has been quoted in media reports saying there is enough scientific evidence to warrant bans on deca. "We don't need to wait another five years or even another two years and let it increase in the environment, while we nail down every possible question we have," she told the Seattle Post-Intelligencer last March.

In a May letter to an assistant administrator at the EPA, Sharon Kneiss, a vice president of the American Chemistry Council, called Rice "a fervent advocate of banning" deca and said she "has no place in an independent, objective peer review." She told the EPA that Rice's role on the panel "calls into question the overall integrity" of the EPA's evaluation of chemicals and that Rice may have influenced the other panelists in their review of deca.

Top EPA officials met with the industry group's representatives in June and promised to take action, according to a letter that EPA Asst. Administrator George Gray sent to the group last month. In that letter, Gray said the EPA found "no evidence" that Rice "significantly influenced the other panelists."

Environmentalists are concerned that Rice's removal could result in a less protective standard.

After EPA officials dismissed her from the five-member panel, they removed her comments from the panel's report on deca and removed all mention of her. Three months later, at the request of the chemical industry group, the EPA added a note to the panel report that Rice was removed "due to a perception of a potential conflict of interest" and that none of her comments were considered in their review of the chemical.

EPA documents show that Rice's comments while serving on the panel focused on technical, scientific issues. For example, she advised the EPA to consider the cumulative effects of not just deca, but chemicals with similar neurological effects.

Rep. Henry Waxman (D-Los Angeles), chairman of the Committee on Oversight and Government Reform, said he was disturbed by Rice's dismissal and the Environmental Working Group's findings about pro-industry panelists.

"If this information is accurate, it raises serious questions about EPA's approach to preventing conflicts of interest on its expert scientific panels," Waxman said.

The conflict of interest policies of another environmental institute, the National Toxicology Program, also has come under fire. Last March, a major consultant for a federal center that evaluates reproductive hazards of chemicals was fired after The Los Angeles Times reported that the firm had financial ties to 50 chemical companies or associations.

Rice specializes in neurotoxins -- chemicals that harm developing brains. Before she went to work for the state of Maine, she was a senior toxicologist at the EPA's National Center for Environmental Research, where she had a major role in setting the EPA's controversial guideline for exposure to mercury in fish.

In 2004, the EPA gave Rice and four colleagues an award for what it called "exceptionally high-quality research" for a study that linked lead exposure to premature puberty in girls.

Many toxicologists and other environmental scientists have said they are highly concerned about flame retardants known as PBDEs, polybrominated diphenyl ethers.

In laboratory tests, PBDEs have been found to skew brain development and alter thyroid hormones, slowing the learning and motor skills of newborn animals.

Two of the compounds, called penta and octa, were banned in 2004. Before the ban, amounts in human breast milk and wildlife were doubling in North America every four to six years, a pace unmatched for any contaminant in at least 50 years. Now they are decreasing.

Scientists had initially thought that the deca compound was not accumulating in people and animals as the other PBDEs were. But it appears that deca turns into other brominated substances when exposed to sunlight, and now many scientists say it, too, is building up in the environment worldwide. Deca has similar effects on animals' developing brains as the banned PBDEs.

The chemical industry contends that low doses pose no danger and that the compound is necessary to prevent fires in many consumer products. In addition to TVs and other electronics, deca is used in furniture textiles, building materials and automobiles. About 56,000 tons were used worldwide in 2001, mostly in the United States and Asia.

Only Maine and Washington state restrict use of deca; both passed laws last year that phase out some uses. Similar bills have been introduced in California but have not passed.

marla.cone@latimes.com

© 2008 The Los Angeles Times